Clustering and External Validity in Randomized Controlled Trials
نویسندگان
چکیده
منابع مشابه
Blindness in Randomized Controlled Trials
In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...
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I would like to propose some concerns, which could affect the external validity of randomised controlled trials in IPF [2, 3]. The first concern is about the diagnostic accuracy of the disease. IPF is a rare disease and no single accurate test for the diagnosis of IPF exists. Studies of the accuracy of diagnosing IPF are performed mostly in tertiary referral centres, and, even in these studies,...
متن کاملExternal validity of randomised controlled trials in idiopathic pulmonary fibrosis.
I would like to propose some concerns, which could affect the external validity of randomised controlled trials in IPF [2, 3]. The first concern is about the diagnostic accuracy of the disease. IPF is a rare disease and no single accurate test for the diagnosis of IPF exists. Studies of the accuracy of diagnosing IPF are performed mostly in tertiary referral centres, and, even in these studies,...
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To date, the external validity of randomized controlled trials (RCTs) on Alzheimer's disease (AD) has been assessed only considering monodimensional variables. Nevertheless, looking at isolated and single characteristics cannot guarantee a sufficient level of appreciation of the AD patients' complexity. The only way to understand whether the two worlds (i.e., research and clinics) deal with the...
متن کاملThe external validity of published randomized controlled trials in primary care
BACKGROUND A criticism of Randomized Controlled Trials (RCTs) in primary care is that they lack external validity, participants being unrepresentative of the wider population. Our aim was to determine whether published primary care-based RCTs report information about how the study sample is assembled, and whether this is associated with RCT characteristics. METHODS We reviewed RCTs published ...
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ژورنال
عنوان ژورنال: SSRN Electronic Journal
سال: 2020
ISSN: 1556-5068
DOI: 10.2139/ssrn.3630707